This combo is built around Inevitable Demise, the affliction warlock talent that increases drain life damage by up to 750%!
This will be combined with a lot of other modifers, including 3 other legendary effects, to be able to destroy enemies within just a few seconds.
The legendary effects we are going to use is Ira da Consumição
This will be stacked before combat, to gain a 30% damage boost to Drain Life. This legendary effect will persist even if you unequip the legendary itself!
It is the same case with the night fae legendary Algibeira com Alma Decomposta
which grants you up to 20% haste and crit, depending on how many enemies are effected by your Soul Rot.
Soul Rot will make your drain life be able to hit up to 5 targets total (4 enemies affected by the debuff, aswell as your main target being another one)
The final legendary we will use is Garra de Endereth
, in order to equip this during the combo, we have to drop combat. We will do that thanks to the Anel Precioso de Espinho Sangrento
We will use take use of the soulbind First Strike from Korayn. Which gives you 25% crit if you used a damage ability on the enemy before they strike you. It is important to use Haunt (if you go single target) or Grimoire of Sacrifice (multi target) since most other affliction spells won't proc the First Strike.
Both the single and multi target version of the combo is built around stacking Wrathful Consumption. Then if you go for single target, you can equip the Claw of Endereth legendary and skip the Soul Rot. (You will instead go for haunt followed by Bane of Shadows, which gives additional damage). Afterwards you drain life and obliterate the enemy within just 2 seconds!
If you go multi target, you equip the Decaying Soul Satchel, and use all consumables and powerups, followed by a Soul Rot, then you use Precious Bloodthorn loop and change gear into your Claw of Endereth legendary.
The command for changing gear is /equip X if you want to add this into a macro.
The macro I use for the powerup is the following:
/use drums of deathly ferocity
/cast dark soul: misery
/cast unending resolve
/use potion of spectral intellect
/use nether ward
/use unchained gladiator's badge of ferocity
/cast soul rot (OR haunt, if you go single target)