I would have to say after over a year of running molten core getting our guilds main tank his second half of his bindings of the wind seeker is another completely epic loot :)
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ill say that the most epic loot would be my first boe epic that dropped while i was killing the furbolg in felwood. It was the hammer of the northern wind and i had never had a bow epic drop b4 so it was very exciting
Most epic thing I think anyway, was me playing on my Death Knight and the assault on Light Hope's Chapel began, 600 Soldiers of the Light against 10000 Scourge Troops. The battle was awsome.
As a dps warrior new to raiding my most epic drop was http://www.wowhead.com/?item=30082 (Talon of Azshara) I was still running around with my s1 weapons and this drops on my first kill of him and as all others have it I get given it.It improved my dps so much I got a regular raid slot and a top pve guild on out server asked me to join them after our guild disbanded.I then went on to clear all bosses in TBC and all content (so far) in wotlkThe only regret is I vendored this sword I would love to have it for the looks and memoriesNibbs, Laughing Skull (Europe)
My Epic loot drop was "Gut Ripper" as a drop from ZF, I was going through with a friend and as we cleared the final boss we decided to go to Gahz'rilla. As we cleared the area the purple dagger dropped. When i found it i was over the moon as it was my first Epic ever!
After several weeks with almost no loot for mei finaly got my Tier 4 shoulders in Gruul :)I Replaced my blue (bush) shoulders and that was like epic for me.
My most epic loot was getting the magisters boots from the postman in stratholme before they were moved onto another NPC, i remeber ll the runs we made their just to get that last piece of teir 1 and then 1 week later i dis enchanted them, had to out in a ticket to ge them back
Destiny. It dropped for me in Dire Maul on a Gordok Tribute run.... on the gray trash bugs off side of one of the major bosses. MY DESTINY IS TO BE AN INSECT SMASHER!
After i wrote the Bad Mojo Mask yesterday i did some thinking, whats better and i decided on 2 it was the last day of brewfest this year and the last chance we had to win the mounts then everyone started going crazy BOTH DROPPED. We had decided in advance to all need on the mounts so i did. And i won them both! :) best drop i ever got