| Rune | Effect |
| Greater Rune of the Void Ritual | Gain Void Ritual, giving all your spells and abilities a chance to increase all secondary stats by 123 every second for 20 seconds. |
| Greater Rune of the Twisted Appendage | Your attacks have a chance to spawn a tentacle, which Mind Flays your target for 163.002 Shadow damage every second for 10 seconds. |
| Greater Rune of Gushing Wound | Your damaging spells and abilities have a chance to cause your target to ooze blood for 453,292 damage over 7 seconds. |
| Greater Rune of Infinite Stars | Your spells and abilities have a chance to strike a nearby enemy with an Infinite Star, dealing 362,226 Arcane damage and increasing their damage taken from your Infinite Stars by 126,779, stacking up to 6 times before resetting. |
| Greater Rune of Echoing Void | Your damaging abilities build the Echoing Void. Each time it builds, Echoing Void has a chance to collapse, dealing 123,156 Shadow damage to all nearby enemies every 1 second until no stacks remain. |
| Greater Rune of Twilight Devastation | Allows your attacks to have a chance to trigger a beam of Twilight Devastation, dealing up to 2.8 million Shadow damage to enemies in front of you. |