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Diablo 4 Alchemist Guide - Season 4
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[Last Updated]:
2024/05/29
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This Wowhead guide covers everything you need to know about the Alchemist in Diablo 4. Topics include finding the Alchemist, upgrading your health potion, crafting elixirs and incense, and refining resources.
Alchemist Basics in Diablo 4 Season 4
Alchemists perform four important functions:
They upgrade your
Healing Potion
. As you progress in levels you can upgrade the efficacy of your healing potion. Note: You can increase the charges of your Healing Potion through the Renown system.
They craft
Elixirs
. Elixirs are temporary stat and experience buffs.
They perform
Transmutation
. This means creating summoning items for use in Uber Bosses, transmuting s to craft Uber Uniques, and refining crafting materials.
They craft
Incense
. Burning crafted Incense provides temporary stat buffs for nearby players.
All services provided by Alchemists are performed in exchange for both a material and gold cost. You can learn more about crafting materials in our Crafting Materials Overview, including what they are used for and where they can be found. Details on increasing the charges of your Health Potion can be found in our Renown guide.
Crafting Materials Overview Renown Overview for Diablo IV
How to Find an Alchemist in Diablo 4
Alchemists are located within all five major towns of Sanctuary, and they can be found in your map by looking for the mortar-and-pestle icon. Currently, no Alchemist resides at the Tree of Whispers hub.
From left-to-right and top-to-bottom, these are the Alchemist locations in Kyovashad, Cerrigar, Ked Bardu, Gea Kul, and Zarbinzet.
Alchemist Services in Diablo 4
Upgrading Your Health Potion
The Alchemist lets you upgrade your healing potion at specific levels in exchange for crafting materials and Gold. Health potion charges can be increased by earning Renown in each region of Sanctuary. Additionally, when players reach the required level to upgrade their healing potion, an upward-facing arrow will appear next to the Alchemist's icon in city maps.
Potion
Effect
Cost
Requires Level 1
Heals 17 Life instantly and 35% of your Maximum Life over 3 seconds.
-
Requires Level 10
Heals 48 Life instantly and 35% of your Maximum Life over 3 seconds.
10
5,000 Gold
Requires Level 20
Heals 80 Life instantly and 35% of your Maximum Life over 3 seconds.
15
10,000 Gold
Requires Level 30
Heals 141 Life instantly and 35% of your Maximum Life over 3 seconds.
245
150,000 Gold
Requires Level 45
Heals 255 Life instantly and 35% of your Maximum Life over 3 seconds.
70
500,000 Gold
Requires Level 60
Heals 378 Life instantly and 35% of your Maximum Life over 3 seconds.
110
15
1,000,000 Gold
Requires Level 70
Heals 559 Life instantly and 35% of your Maximum Life over 3 seconds.
180
20
5
3,000,000 Gold
Requires Level 80
Heals 827 Life instantly and 35% of your Maximum Life over 3 seconds.
290
25
10
5,000,000 Gold
Requires Level 90
Heals 1,274 Life instantly and 35% of your Maximum Life over 3 seconds.
425
30
20
7,000,000 Gold
Elixirs
Brewing Elixirs
Elixirs grant temporary buffs to your stats. There are many different elixirs in Diablo 4. One effect shared by them is that they boost your experience gain.
You can only have one Elixir active at a time.
Quest Elixir
Elixir
Effect
Cost
Requires Level 35
For the next 30 minutes: Increases Maximum Life by 15% and Poison Resist by 20%. Experience gained is increased by 8%.
50
35
150
150
1,000 Gold
Basic Elixirs
Elixir
Effect
Cost
Requires Level 40
For the next 30 minutes: Increases Cold Resistance by +20% and Maximum Cold Resistance by +4%. Experience gained is increased by 5%.
20
300
3,000 Gold
Requires Level 40
For the next 30 minutes: Increases Fire Resistance by +20% and Maximum Fire Resistance by +4%. Experience gained is increased by 5%.
20
300
3,000 Gold
Requires Level 40
For the next 30 minutes: Increases Lightning Resistance by +20% and Maximum Lightning Resistance by +4%. Experience gained is increased by 5%.
20
300
3,000 Gold
Requires Level 40
For the next 30 minutes: Increases Poison Resistance by +20% and Maximum Poison Resistance by +4%. Experience gained is increased by 5%.
20
300
3,000 Gold
Requires Level 40
For the next 30 minutes: Increases Shadow Resistance by +20% and Maximum Shadow Resistance by +4%. Experience gained is increased by 5%.
20
300
3,000 Gold
Requires Level 20
For the next 30 minutes: Increases Armor by +300 and Thorns by 150. Experience gained is increased by 5%.
10
100
2,000 Gold
Requires Level 20
For the next 30 minutes: Increases Maximum Life by 10% and Experience gained is increased by 5%.
10
200
2,000 Gold
Requires Level 20
For the next 30 minutes: Grants 10% Resource Cost Reduction and 10 Maximum Resource. Experience gained is increased by 5%.
20
2,000 Gold
Requires Level 10
For the next 30 minutes: Increases Overpower damage by 7% and Vulnerable damage by 7%. Experience gained is increased by 5%.
5
1,000 Gold
Requires Level 10
For the next 30 minutes: Increases Attack Speed by 7% and Lucky Hit by 7%. Experience gained is increased by 5%.
5
1,000 Gold
Requires Level 10
For the next 30 minutes: Increases Critical Strike Chance by 4% and Critical Strike Damage by 25%. Experience gained is increased by 5%.
5
1,000 Gold
Advanced Elixirs
Elixir
Effect
Cost
Requires Level 50
For the next 30 minutes: Increases Attack Speed by 15% and Lucky Hit by 15%. Experience gained is increased by 8%.
10
10
2,000 Gold
Requires level 50
For the next 30 minutes: Increases Cold Resistance by +30% and Maximum Cold Resistance by +6%. Experience gained is increased by 8%.
40
30
300
6,000 Gold
Requires Level 50
For the next 30 minutes: Increases Overpower damage by 15% and Vulnerable damage by 15%. Experience gained is increased by 8%.
10
10
2,000 Gold
Requires Level 50
For the next 30 minutes: Increases Fire Resistance by +30% and Maximum Fire Resistance by +6%. Experience gained is increased by 8%.
40
30
300
6,000 Gold
Requires Level 50
For the next 30 minutes: Increases Maximum Life by 20% and Experience gained is increased by 8%.
20
20
200
4,000 Gold
Requires Level 50
For the next 30 minutes: Increases Armor by +500 and Thorns by 250. Experience gained is increased by 8%.
20
20
200
4,000 Gold
Requires Level 50
For the next 30 minutes: Increases Lightning Resistance by +30% and Maximum Lightning Resistance by +6%. Experience gained is increased by 8%.
40
30
300
6,000 Gold
Requires Level 50
For the next 30 minutes: Increases Poison Resistance by +30% and Maximum Poison Resistance by +6%. Experience gained is increased by 8%.
40
30
300
6,000 Gold
Requires Level 50
For the next 30 minutes: Increases Critical Strike Chance by 6% and Critical Strike Damage by 35%. Experience gained is increased by 8%.
10
10
2,000 Gold
Requires Level 50
For the next 30 minutes: Grants 20% Resource Cost Reduction and 25 Maximum Resource. Experience gained is increased by 8%.
10
10
2,000 Gold
Requires Level 50
For the next 30 minutes: Increases Shadow Resistance by +30% and Maximum Shadow Resistance by +6%. Experience gained is increased by 8%.
40
30
300
6,000 Gold
Seasonal Elixirs
Elixir
Effect
Cost
Requires Level 10
For the next 315 minutes: After killing an enemy, holy bolts fire from the corpse of that enemy. Experience gained is increased by 6%.
350
2,000 Gold
Requires Level 10
For the next 15 minutes: After killing an enemy, increase Movement Speed by 3% for 5 seconds, stacking up to 15 times. Experience gained is increased by 6%.
350
2,000 Gold
Requires Level 10
For the next 60 minutes: Increases Helltide Monster Level by 10. Increases Abberant Cinder drop rate and threat gain.
Drop from Hellbourne in WT3 or higher
Transmutation
Summoning Item
Similar to the Crafting Materials, Summoning Items can be found throughout Sanctuary. Once these items are refined by the Alchemist they can be combined to summon Uber Bosses for a chance at dropping Uniques.
Item
Description
Cost
Transmute Malignant -
Body Part
Contains a Gurgling Head, Blackened Femur, or Trembling Hand used for summoning enemy below the Tree of Whispers within Malignant Burrow.
1
1
5
20,000 Gold
Transmute Malignant -
Body Part
Contains a Gurgling Head, Blackened Femur, or Trembling Hand used for summoning enemy below the Tree of Whispers within Malignant Burrow.
1
1
5
20,000 Gold
Transmute Malignant -
Body Part
Contains a Gurgling Head, Blackened Femur, or Trembling Hand used for summoning enemy below the Tree of Whispers within Malignant Burrow.
1
1
5
20,000 Gold
Transmute Malignant - Femur
Assembled beneath the Tree of Whispers within Malignant Burrow to summon a powerful enemy. Collected from Whisper caches.
Can be Refined at the Alchemist.
1
4
15
50,000 Gold
Transmute Malignant - Head
Assembled beneath the Tree of Whispers within Malignant Burrow to summon a powerful enemy. Collected from Whisper caches.
Can be Refined at the Alchemist.
1
4
15
50,000 Gold
Transmute Malignant - Hand
Assembled beneath the Tree of Whispers within Malignant Burrow to summon a powerful enemy. Collected from Whisper caches.
Can be Refined at the Alchemist.
1
4
15
50,000 Gold
Transmute Sparks
Alchemists also have the ability to craft Uber Uniques through the use of s, which are created by salvaging duplicate and undesired Uber Uniques at the Blacksmith. Salvaging 1 Uber Unique yields 1 .
Item
Description
Cost
Unique Staff (Druid, Sorcerer)
+35.0% Damage to Crowd Controlled Enemies
+35.0% Damage
+20.0% Attack Speed
+16.0% Critical Strike Chance
Lucky Hit: Up to a +28.0% Chance to Stun
Gain a random Shrine effect for 20 seconds after killing an Elite enemy. Can only occur once every 30 seconds.
4 s
50,000,000
Unique Helm (All Classes)
+18 All Stats
+10.0% Attack Speed
+2.0% Life Steal
+60.0% Poison Resistance
Lucky Hit: Up to a 20% chance to trigger a poison nova that applies 750 Poisoning damage over 5 seconds to enemies in the area.
4 s
50,000,000
Unique Sword (Barbarian, Necromancer, Rogue)
+17.5% Critical Strike Damage
+17.5% Damage
+19.5% Core Damage
26.0% Maximum Life
Lucky Hit: Up to a 5% Chance to Heal +1,058 Life
Lucky Hit: Up to a 25% chance to deal 450 Shadow damage to surrounding enemies and reduce their damage done by 20% for 5 seconds.
4 s
50,000,000
Unique Helm (All Classes)
+28 All Stats
+1,528 Maximum Life
12.0% Resource Generation
7.0% Cooldown Reduction
Gain 20% Damage Reduction. In addition, gain +4 Ranks to all Skills.
4 s
50,000,000
Unique Amulet (All Classes)
+25.0% Resistance to All Elements
+36 All Stats
+17.5% Movement Speed
+70.5% Damage while Healthy
12.0% Resource Generation
Gain 60 Maximum Resource.
When taking damage, 75% is drained as 2 Resource for every 1% of Maximum Life you would have lost.
4 s
50,000,000
Unique Ring (All Classes)
+10.0% Resistance to All Elements
+10.0% Resistance to All Elements
+5.0% Critical Strike Chance
+17.5% Critical Strike Damage
+19.5% Core Skill Damage
+6.0% Lucky Hit Chance
Spending your Primary Resource reduces the Resource cost of your Skills and increases your damage by 10% for 3 seconds, up to 40%.
4 s
50,000,000
Unique Two-Handed Sword (Barbarian, Necromancer)
+35.0% Critical Strike Damage
+72 All Stats
+56.0% Damage
+3,056 Maximum Life
Ignores Durability Loss
Increases your Critical Strike Damage by 100%. The other properties on this weapon can roll higher than normal.
4 s
50,000,000
Unique Chest Armor (All Classes)
+11.2% Resistance to All Elements
+5.0% Maximum Resistance to All Elements
+18 All Stats
10% Damage Reduction
When at full Life, your Skill unleash a divine barrage dealing 98 damage.
4 s
50,000,000
You can learn more about crafting Uber Uniques in our Uber Unique Crafting Guide, including what they are used for and where they can be found.
Uber Unique Crafting Guide - Season 4
Crafting Materials
Players are able to exchange bulk amounts of Masterworking Crafting Materials for others. While Masterworking itself takes places through the Blacksmith, Transmutation of Masterworking materials happens through the Alchemist.
Item
Description
Cost
to
1
600 Gold
to
1
200 Gold
Levelling Item
These items are meant to be used as a catch-up mechanic when leveling alts. Its only recommended for those players with a main character that's flushed with Gold, otherwise, there are many cheaper sources for farming Legendary Items throughout Sanctuary.
Item
Description
Cost
Contains a Legendary item. Available from level 20-50.
94
94
960,500 Gold
Incense
Crafting Incense
The effects from Incense in Diablo 4 apply to grouped and ungrouped players. For example, if you were to burn Incense prior to a World Boss, both party and solo players would receive the benefit. Also, Incense is categorized by type, and only one Incense of a type may be active at a time. This means that it's possible to use and stack the benefits of different Incense types. Incense grants a bonus to experience, but the experience bonus does not stack. Incense effects persist through death.
Incense
Incense
Effect
Cost
Requires Level 45
Increases Armor by +200 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
55
1
30
1,500 Gold
Requires Level 50
Increases Strength by 25 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
60
2
35
2,500 Gold
Requires Level 50
Increases Willpower by 25 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
60
2
35
2,000 Gold
Requires Level 50
Increases Dexterity by 25 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
60
2
35
2,000 Gold
Requires Level 50
Increases Intelligence by 25 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
60
2
35
2,000 Gold
Requires Level 55
Increases Fire, Cold, and Shadow Resistances by +15% and their Maximum Resistances by +2% for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
70
4
3
50
50
2,500 Gold
Requires Level 55
Increases Lightning, Cold, and Poison Resistances by +15% and their Maximum Resistances by +2% for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
65
4
3
50
50
2,500 Gold
Requires Level 80
Increases chance to Dodge by 5% for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type I incense.
90
9
9
5,000 Gold
Requires Level 60
Increases Maximum Life by 500 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type II incense.
75
5
4
140
3,000 Gold
Requires Level 65
Increases All Stats by 15 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type II incense.
80
6
6
3,500 Gold
Requires Level 70
Increases Thorns by 250 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type II incense.
80
7
6
160
4,000 Gold
Requires Level 75
Increases Resistance to All Elements by +10%, Maximum Resistance for All Elements by +1%, and Armor by +150 for all nearby players and increases Experience by 5%. Lasts 20 minutes.
This is a type II incense
.
85
8
7
85
85
4,500 Gold
Requires Level 100
Increases All Stats by 40 and Critical Strike and Overpower Damage by 5% for every nearby player and increases Experience by 5%. Lasts 20 minutes.
This is a type III incense.
100
10
10
100
100
6,000 Gold
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